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In the only human tests, mitochondrial transplants appear to revive and restore heart muscle in infants that was injured in operations to repair congenital heart defects. For Georgia, though, the transplant was a long shot — a heart attack is different from a temporary loss of blood during an operation, and the prognosis is stark. There is only a short time between the onset of a heart attack and the development of scar tissue where once there were living muscle cells. The problem was that no one knew when the baby’s heart attack had occurred. Still, said Dr. Sitaram Emani, a pediatric heart surgeon who administered the transplant, there was little risk to the infant and a chance, though slim, that some cells affected by her heart attack might still be salvageable. “They gave her a fighting chance,” said the infant’s mother, Kate Bowen, 36, of Duxbury, Mass. Dr. Jesse Esch, right, with Brian Quinn, a cardiology fellow, performing a mitochondrial transplant on Georgia Bowen. Angiograms showing the infant’s coronary arteries and the catheter can be seen on the monitor.CreditKatherine Taylor for The New York Times Dr. James McCully prepared to inject mitochondria for Georgia Bowen during her operation.
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